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Deficiencies of Runx3 and tissue-resident CD4 <sup>+</sup> intestinal epithelial lymphocytes link intestinal dysbiosis and inflammation in mouse and human spondyloarthropathy

2022-07-30

Abstract excerpt

<h4>Objective</h4> Disturbances in immune regulation, intestinal microbial dysbiosis and intestinal inflammation characterize ankylosing spondylitis (AS), which is associated with RUNX3 loss-of-function variants. ZAP70 W163C mutant (SKG) mice have reduced ZAP70 signaling, spondyloarthritis and ileitis. At intestinal epithelial interfaces, lamina propria Foxp3 + regulatory T cells (Treg) and intraepithelial CD4...

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Literature Corpus work
269252ff-5192-5872-a085-a6d29a0a41fd
DOI
10.1101/2022.07.28.501834
Open publication

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Deficiencies of Runx3 and tissue-resident CD4 <sup>+</sup> intestinal epithelial lymphocytes link intestinal dysbiosis and inflammation in mouse and human spondyloarthropathyDOI 10.1101/2022.07.28.501834
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