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Article

Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1.

Seminars in immunology - 1 Aug 2006

Sakaguchi Shimon, Sakaguchi Noriko, Yoshitomi Hiroyuki, Hata Hiroshi, Takahashi Takeshi, Nomura Takashi

Abstract excerpt

A point mutation of the gene encoding ZAP-70, a key signal transduction molecule in T cells, results in spontaneous development of T cell-mediated autoimmune arthritis in mice homozygous for the mutation. The genetic anomaly alters differentiation and selection of T cells in the thymus, leading to thymic production of arthritogenic autoimmune T cells. The arthritogenic T cells persist in the periphery and elicit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16713715
DOI: 10.1016/j.smim.2006.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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