Article

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states

2021-08-24

Abstract excerpt

<h4>ABSTRACT</h4> In response to central nervous system injury or disease, astrocytes become reactive, adopting context-dependent states and functional outputs. Certain inflammatory insults induce reactive astrocytes that lose homeostatic functions and gain harmful outputs through cellular pathways that are not fully understood. Here, we combined single-cell transcriptomics with CRISPRi screening in human iPSC-de...

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Literature Corpus work: f7a9a2cd-7f12-515c-a4b2-74ea550aeaae
DOI: 10.1101/2021.08.23.457400

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