Article

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex

2023-02-27

Abstract excerpt

Traumatic brain injury leads to a highly orchestrated immune- and glial cell response partially responsible for long-lasting disability and the development of secondary neurodegenerative diseases. A holistic understanding of the mechanisms controlling the responses of specific cell types and their crosstalk is required to develop an efficient strategy for better regeneration. Here, we combined spatial and single-c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 935c6900-5a5f-5e98-a206-4a769d788dad
DOI: 10.1101/2023.02.24.529840

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortexDOI 10.1101/2023.02.24.529840Read

Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain InjurySemantic proximity Read

Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon responseSemantic proximity Read

Integration of single-cell and bulk RNA sequencing data reveals key cell types and regulators in traumatic brain injurySemantic proximity Read

A spatiotemporal immune atlas of subarachnoid hemorrhage from single-cell and spatial transcriptomicsSemantic proximity Read

Lesion-remote astrocytes govern microglia-mediated white matter repairSemantic proximity Read

The meningeal transcriptional response to traumatic brain injury and agingSemantic proximity Read

Single-cell transcriptomics of resected human traumatic brain injury tissues reveals acute activation of endogenous retroviruses in oligodendrogliaSemantic proximity Read

Microglia and infiltrating T-cells adopt long-term, age-specific, transcriptional changes after traumatic brain injurySemantic proximity Read

Neuroinflammation: Integrated Nervous Tissue Response through Intercellular Interactions at the "Whole System" Scale.Semantic proximity Read

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive statesSemantic proximity Read

Controlled Cortical Impact and Craniotomy Induce Strikingly Similar Profiles of Inflammatory Gene Expression, but with Distinct KineticsSemantic proximity Read