Article
The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.
Molecular neurobiology - 1 Aug 2016
Michelucci Alessandro, Bithell Angela, Burney Matthew J, Johnston Caroline E, Wong Kee-Yew, Teng Siaw-Wei, Desai Jyaysi, Gumbleton Nigel, Anderson Gregory, Stanton Lawrence W, Williams Brenda P, Buckley Noel J
Abstract excerpt
Although the adult brain contains neural stem cells (NSCs) that generate new neurons throughout life, these astrocyte-like populations are restricted to two discrete niches. Despite their terminally differentiated phenotype, adult parenchymal astrocytes can re-acquire NSC-like characteristics following injury, and as such, these 'reactive' astrocytes offer an alternative source of cells for central nervous system...
Topics
- Animals
- Animals, Newborn
- Astrocytes
- Bone Morphogenetic Protein 4
- Cell Dedifferentiation
- Cell Line
- Cell Proliferation
- Central Nervous System
- Epigenesis, Genetic
- Gene Expression Profiling