Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.

Molecular neurobiology - 1 Aug 2016

Michelucci Alessandro, Bithell Angela, Burney Matthew J, Johnston Caroline E, Wong Kee-Yew, Teng Siaw-Wei, Desai Jyaysi, Gumbleton Nigel, Anderson Gregory, Stanton Lawrence W, Williams Brenda P, Buckley Noel J

Abstract excerpt

Although the adult brain contains neural stem cells (NSCs) that generate new neurons throughout life, these astrocyte-like populations are restricted to two discrete niches. Despite their terminally differentiated phenotype, adult parenchymal astrocytes can re-acquire NSC-like characteristics following injury, and as such, these 'reactive' astrocytes offer an alternative source of cells for central nervous system...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Astrocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bone Morphogenetic Protein 4

Share to Cell Dedifferentiation

Share to Central Nervous System

Share to Neural Stem Cells

Share to Neurogenesis

Share to NF-kappa B

Source

Open in PubMed Open full text

Identifiers

PMID: 26138449
DOI: 10.1007/s12035-015-9296-x
PMCID: PMC4937102

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.PMID 26138449Read ↗

Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation.Semantic proximity Read ↗

Role of astrocytes in the pathogenesis of perinatal brain injurySemantic proximity Read ↗

Protective Functions of Reactive Astrocytes Following Central Nervous System Insult.Semantic proximity Read ↗

NF-κB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells.Semantic proximity Read ↗

Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes.Semantic proximity Read ↗

Signaling molecules regulating phenotypic conversions of astrocytes and glial scar formation in damaged nerve tissues.Semantic proximity Read ↗

NFIB induces functional astrocytes from human pluripotent stem cell-derived neural precursor cells mimicking in vivo astrogliogenesis.Semantic proximity Read ↗

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system.Semantic proximity Read ↗

Functional roles of reactive astrocytes in neuroinflammation and neurodegenerationSemantic proximity Read ↗

Diversity of astrocyte functions and phenotypes in neural circuits.Semantic proximity Read ↗

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.Semantic proximity Read ↗

Astroglial activation: Current concepts and future directionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.