Article
SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity.
The Journal of clinical investigation - 15 Nov 2022
Zhang Weifeng, Xiao Dan, Li Xing, Zhang Yuan, Rasouli Javad, Casella Giacomo, Boehm Alexandra, Hwang Daniel, Ishikawa Larissa Lw, Thome Rodolfo, Ciric Bogoljub, Curtis Mark T, Rostami Abdolmohamad, Zhang Guang-Xian
Abstract excerpt
Astrocytes are highly heterogeneous in their phenotype and function, which contributes to CNS disease, repair, and aging; however, the molecular mechanism of their functional states remains largely unknown. Here, we show that activation of sirtuin 1 (SIRT1), a protein deacetylase, played an important role in the detrimental actions of reactive astrocytes, whereas its inactivation conferred these cells with...
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