Article

Chemical inhibition of pathological reactive astrocytes promotes neural protection

2021-11-04

Abstract excerpt

Disease, injury, and aging induce reactive astrocyte states with pathological functions 1-4 . In neurodegenerative diseases, inflammatory reactive astrocytes are abundant and contribute to progressive cell loss. Modulating the state or function of these reactive astrocytes thereby represents an attractive therapeutic goal 5,6 . Leveraging a cellular phenotypic screening platform, we show that chemical inhibitors...

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Literature Corpus work: 2b5a539a-a665-5174-bf43-fd55f82443e0
DOI: 10.1101/2021.11.03.467083

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