Article

Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

2022-02-22

Abstract excerpt

Astrocytes are critical components of the neurovascular unit that support blood-brain barrier (BBB) function in brain microvascular endothelial cells (BMECs). Transformation of astrocytes to a reactive state in response to injury and disease can be protective or harmful to BBB function, but the underlying mechanisms for these effects remain mostly unclear. Using a human induced pluripotent stem cell (iPSC)-derived...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e2c7307-d0f4-54c1-8a5e-e84edd169956
DOI: 10.1101/2022.02.21.481336

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reactive astrocytes transduce blood-brain barrier dysfunction through a TNFα-STAT3 signaling axis and secretion of alpha 1-antichymotrypsinDOI 10.1101/2022.02.21.481336Read

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive statesSemantic proximity Read

Cellular origin and therapeutic potential of SERPINA3N in ischemic strokeSemantic proximity Read

TNFα-Induced Endothelial Extracellular Vesicles Regulate Astrocyte Function: An Integrated Transcriptomic and Proteomic StudySemantic proximity Read

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states.Semantic proximity Read

HTRA1 deficiency in <i>COL4A1</i> mutant hiPSC-derived astrocytes: a convergent mechanism of cerebral small vessel diseaseSemantic proximity Read

Chemical inhibition of pathological reactive astrocytes promotes neural protectionSemantic proximity Read

TNFα hinders FGF4 efficacy to mitigate ALS astrocyte dysfunction and cGAS-STING pathway-induced innate immune reactivitySemantic proximity Read

Injury-transduced SerpinOLs modulate neuroinflammation and glial activation in the diseased and non-diseased CNSSemantic proximity Read

Blocking A1 astrocyte conversion with semaglutide attenuates blood-brain barrier disruption in mice after middle cerebral artery occlusionSemantic proximity Read

ADGRG1 blockade drives astrocytes into the extracellular matrix to reduce glial scar sizeSemantic proximity Read

Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization.Semantic proximity Read

Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system.Semantic proximity Read