Article

Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPS cells

2017-11-27

Abstract excerpt

Both human and mouse fibroblasts can be reprogrammed to pluripotency with Oct4, Sox2, Klf4, and c-Myc (OSKM) transcription factors. While both systems generate pluripotency, human reprogramming takes considerably longer than mouse. To assess additional similarities and differences, we sought to compare the binding of the reprogramming factors between the two systems. In human fibroblasts, the OSK factors initially...

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Literature Corpus work: f71d0a93-1cc6-54b0-8758-eededbab94b2
DOI: 10.1101/225326

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