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Deeply conserved super-enhancers maintain stem cell pluripotency in placental mammals

2022-05-03

Abstract excerpt

Despite pluripotent stem cells sharing key transcription factors, their maintenance involves distinct genetic inputs. Emerging evidence suggests that super-enhancers (SEs) can function as master regulatory hubs to control cell identity and pluripotency in humans and mice. However, whether pluripotency-associated SEs share a deep evolutionary origin in mammals remains elusive. Here, we performed comprehensive compa...

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Identifiers and source

Literature Corpus work
d5775e23-2552-5332-9beb-9a458def10cd
DOI
10.1101/2022.05.03.490430
Open publication

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Deeply conserved super-enhancers maintain stem cell pluripotency in placental mammalsDOI 10.1101/2022.05.03.490430
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