Article

High-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State Pluripotency

2017-09-07

Abstract excerpt

The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) with four transcription factors Oct4, Sox2, Klf4 and cMyc (abbreviated as OSKM) 1 has provoked interest to define the molecular characteristics of this process 2-7 . Despite important progress, the dynamics of epigenetic reprogramming at high resolution in correctly reprogrammed iPSCs and throughout the entire process remain large...

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Literature Corpus work: 51e15e93-e762-5229-9761-286c219330f4
DOI: 10.1101/184135

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