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Article

Sox2 and Klf4 as the Functional Core in Pluripotency Induction without Exogenous Oct4

1 Nov 2019

Abstract excerpt

Ectopic expression of Oct4, Sox2, Klf4, and c-Myc can reprogram differentiated somatic cells into induced pluripotent stem cells (iPSCs). For years, Oct4 has been considered the key reprogramming factor core of the four factors. Here, we challenge this view by reporting a core function of Sox2 and Klf4 in reprogramming. We found that polycistronic expression of Sox2 and Klf4 was sufficient to induce pluripotency...

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Identifiers

PMID: 31722212
DOI: 10.1016/j.celrep.2019.10.026

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