Article

KLF4 binding is involved in the organization and regulation of 3D enhancer networks during acquisition and maintenance of pluripotency

2018-08-01

Abstract excerpt

<h4>SUMMARY</h4> Cell fate transitions are accompanied by global transcriptional, epigenetic and topological changes driven by transcription factors (TFs), as is strikingly exemplified by reprogramming somatic cells to pluripotent stem cells (PSCs) via expression of OCT4, KLF4, SOX2 and cMYC. How TFs orchestrate the complex molecular changes around their target gene loci in a temporal manner remains incompletely...

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Literature Corpus work: 62251f58-dfee-5b53-a117-41522e14db46
DOI: 10.1101/382473

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