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An Unbiased Approach to Identify Cellular Reprogramming Inducible Enhancers

2024-10-31

Abstract excerpt

Cellular reprogramming of somatic cells towards induced pluripotency is a multistep stochastic process mediated by the transcription factors Oct4, Sox2, Klf4 and c-Myc (OSKM), which orchestrate global epigenetic and transcriptional changes. We performed a large-scale analysis of integrated ChIP-seq, ATAC-seq and RNA-seq data and revealed the spatiotemporal highly dynamic pattern of OSKM DNA binding during reprogra...

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Literature Corpus work
c4bdef96-5218-5ab3-9ffc-5febbfd26d22
DOI
10.20944/preprints202410.2527.v1
Open publication

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An Unbiased Approach to Identify Cellular Reprogramming Inducible EnhancersDOI 10.20944/preprints202410.2527.v1
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