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Article

Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming.

Stem cell reports - 9 Jun 2015

Tanaka Yoshiaki, Hysolli Eriona, Su Juan, Xiang Yangfei, Kim Kun-Yong, Zhong Mei, Li Yumei, Heydari Kartoosh, Euskirchen Ghia, Snyder Michael P, Pan Xinghua, Weissman Sherman Morton, Park In-Hyun

Abstract excerpt

Reprogramming of somatic cells produces induced pluripotent stem cells (iPSCs) that are invaluable resources for biomedical research. Here, we extended the previous transcriptome studies by performing RNA-seq on cells defined by a combination of multiple cellular surface markers. We found that transcriptome changes during early reprogramming occur independently from the opening of closed chromatin by OCT4, SOX2,...

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Source

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Identifiers

PMID: 26004630
DOI: 10.1016/j.stemcr.2015.04.009
PMCID: PMC4471828

Genes

CCNE1
KLF4
MYC
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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