Article

Integrated transcriptome analysis of Huntington’s disease iPSC-derived and mouse astrocytes implicates dysregulated synaptogenesis, actin, and astrocyte maturation

2022-07-31

Abstract excerpt

<h4>Summary</h4> Huntington’s disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat within the Huntingtin ( HTT ) gene having dysregulated cellular homeostasis in the central nervous system, particularly in the striatum and cortex. Astrocytes establish and maintain neuronal functions through the secretion of soluble factors and physical interactions with other neurovascular unit cell type...

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Literature Corpus work: f67b7bb8-db5d-5035-a4fd-8801b4dd1c1f
DOI: 10.1101/2022.07.28.501170

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