Article

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease

2022-12-07

Abstract excerpt

<h4>ABSTRACT</h4> Astrocytes play a critical role in brain homeostasis and normal functions but their changes along the spatiotemporal progression of Alzheimer’s disease (AD) neuropathology remain largely unknown. Here we performed single-nucleus RNA-sequencing on brain regions along the stereotypical progression of AD pathology from donors ranging the entire normal aging-AD continuum comprising 628,943 astrocyte...

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Literature Corpus work: be7ee40d-0303-5cd3-95cf-c1ee0c422125
DOI: 10.1101/2022.12.03.518999

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