Article

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state

2023-09-12

Abstract excerpt

Huntington disease (HD) is an incurable neurodegenerative disease characterized by neuronal loss and astrogliosis. One hallmark of HD is the selective neuronal vulnerability of striatal medium spiny neurons. To date, the underlying mechanisms of this selective vulnerability have not been fully defined. Here, we employed a multi-omic approach including single nucleus RNAseq (snRNAseq), bulk RNAseq, lipidomics, HTT...

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Literature Corpus work: 6f4cb3b7-07ff-590c-b0ad-0e180cd84fa0
DOI: 10.1101/2023.09.08.556867

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