Article

Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington’s Disease and Possible Therapeutic Avenues

2023-05-01

Abstract excerpt

<h4>SUMMARY</h4> Huntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of CAG repeats in exon 1 of the HTT gene, ultimately resulting in the generation of a mutant HTT (mHTT) protein. Although mHTT is expressed in various tissues, it significantly affects medium spiny neurons (MSNs) in the striatum, resulting in their loss and the subsequent motor function impairment in HD. While HD sy...

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Literature Corpus work: 633ee3ff-8363-5490-9b67-8174ed218477
DOI: 10.1101/2023.04.30.538872

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