Article

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

2018-07-31

Abstract excerpt

<h4>Summary</h4> Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 iPSC donor and 13 subclonal lines across nine time points over 5 broad conditions: self-renewal, early neuronal differentiation, neural precursor cells (NPCs), assembled rosettes, and differentiated neuronal cells that we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70569473-714d-5a88-9bd7-6cfbf0361754
DOI: 10.1101/380758

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCsDOI 10.1101/380758Read

Insights for disease modeling from single cell transcriptomics of iPSC-derived Ngn2-induced neurons and astrocytes across differentiation time and co-cultureSemantic proximity Read

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespanSemantic proximity Read

Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neuronsSemantic proximity Read

Identification and characterization of functional modules reflecting transcriptome transition during human neuron maturationSemantic proximity Read

An integrated transcriptomic cell atlas of human neural organoidsSemantic proximity Read

Joint profiling of cell morphology and gene expression during <i>in vitro</i> neurodevelopmentSemantic proximity Read

Single Cell transcriptional analysis of <i>ex vivo</i> models of cortical and hippocampal development identifies unique longitudinal trendsSemantic proximity Read

NeuRoDev resolves lifelong temporal and cellular variation in human cortical gene expressionSemantic proximity Read

Long-term co-maturation of stem cell-derived microglia and neuronal networks: an optimized platform to assess human microglial contribution to neuronal functionSemantic proximity Read

Transcriptional Heterogeneity Reveals a Synaptic Gene Program in Developing and Adult Human Oligodendrocyte Precursor CellsSemantic proximity Read

Brain regional identity and cell type specificity landscape of human cortical organoid modelsSemantic proximity Read

Coupled transcriptomic divergence establishes a human-specific synaptic glial precursor stateSemantic proximity Read