Characterization of isolated human astrocytes from aging brain

Abstract excerpt

<h4>ABSTRACT</h4> Astrocytes have multiple crucial roles, including maintaining brain homeostasis and synaptic function, performing phagocytic clearance and responding to injury and repair. It has been suggested that astrocyte performance is progressively impaired with aging, leading to imbalances in the brain’s internal milieu that eventually impact neuronal function and leads to neurodegeneration. Until now most...

Topics

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• Actins
• Apolipoproteins E
• Astrocytes
• Glial Fibrillary Acidic Protein
• Microarray Analysis
• Microdissection
• Postmortem Changes
• Temporal Lobe

Identifiers and source

Literature Corpus work

ac127092-e28c-5e0b-ae07-c8177c5dc1d5

DOI

10.1101/2025.02.04.25321542