Article

Mapping the glial transcriptome in Huntington’s disease using snRNAseq: Selective disruption of glial signatures across brain regions

2022-09-10

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD) is a severely debilitating, autosomal dominant neurodegenerative disease with a fatal outcome. There is accumulating evidence of a prominent role of glia in the pathology of HD, and we investigated this by conducting single nuclear RNA sequencing (snRNAseq) of human post mortem brain in four differentially affected regions; caudate nucleus, frontal cortex, hippocampus a...

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Literature Corpus work: b5b823ee-e970-513e-a2d3-f121852ff2d5
DOI: 10.1101/2022.09.10.507291

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