Article

Spreading alpha-synuclein Oligomers Trigger Astrocyte Changes and Astrocyte-Glutamatergic Neuron system dysfunction in an Age-related Manner

2025-08-11

Abstract excerpt

<h4>Background</h4> Parkinson’s disease (PD) is characterized by the progressive accumulation and spatio-temporal spread of α-synuclein (α-syn) oligomers and a progressive loss of dopaminergic neurons. Many studies showed a direct cytotoxic effect of α-syn oligomers on neurons. Other cell types including astrocytes were also reported to show specific responses to α-syn and are believed to play a role in the sprea...

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Literature Corpus work: 79fe3c31-8070-5225-8356-0baf52e46088
DOI: 10.1101/2025.08.08.669249

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