Article

Single-nucleus RNA-seq identifies Huntington disease astrocyte states

2019-10-10

Abstract excerpt

Huntington Disease (HD) is an inherited movement disorder caused by expanded CAG repeats in the Huntingtin gene. We have used single nucleus RNASeq (snRNASeq) to uncover cellular phenotypes that change in the disease, investigating single cell gene expression in cingulate cortex of patients with HD and comparing the gene expression to that of patients with no neurological disease. In this study, we focused on astr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d13c19f-e0ab-5545-b4ff-10ed75af5b75
DOI: 10.1101/799973

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-nucleus RNA-seq identifies Huntington disease astrocyte statesDOI 10.1101/799973Read

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte stateSemantic proximity Read

Mapping the glial transcriptome in Huntington’s disease using snRNAseq: Selective disruption of glial signatures across brain regionsSemantic proximity Read

Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to Huntington’s disease mutationsSemantic proximity Read

Single-cell atlas of progressive supranuclear palsy reveals a distinct hybrid glial cell populationSemantic proximity Read

snRNA-seq of Huntington’s disease mice reveals vulnerability profiles of cortical cell typesSemantic proximity Read

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s diseaseSemantic proximity Read

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s diseaseSemantic proximity Read

Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations.Semantic proximity Read

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disordersSemantic proximity Read

Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer’s diseaseSemantic proximity Read

Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use DisorderSemantic proximity Read

Integrated transcriptome analysis of Huntington’s disease iPSC-derived and mouse astrocytes implicates dysregulated synaptogenesis, actin, and astrocyte maturationSemantic proximity Read