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L-DOPA induces spatially discrete changes in gene expression in the forebrain of mice with a progressive loss of dopaminergic neurons

2025-02-17

Abstract excerpt

<h4>ABSTRACT</h4> L-3,4-Dihydroxyphenylalanine (L-DOPA) is effective at alleviating motor impairments in Parkinson’s disease (PD) patients but has mixed effects on nonmotor symptoms and causes adverse effects after prolonged treatment. Here, we analyzed the spatial profile of L-DOPA-induced gene expression in the forebrain of mice with an inducible progressive loss of dopaminergic neurons (the TIF-IA DATCreERT2...

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Literature Corpus work
f65ffe5f-698c-5648-856e-56acb18874a5
DOI
10.1101/2025.02.13.638140
Open publication

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L-DOPA induces spatially discrete changes in gene expression in the forebrain of mice with a progressive loss of dopaminergic neuronsDOI 10.1101/2025.02.13.638140
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