Article

Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2 <sup>G2019S</sup> model of Parkinson’s disease

2024-06-08

Abstract excerpt

Several studies have revealed that midbrain dopamine (DA) neurons, even within a single neuroanatomical area, display heterogeneous properties. In parallel, studies using single cell profiling techniques have begun to cluster DA neurons into subtypes based on their molecular signatures. Recent work has shown that molecularly defined DA subtypes within the substantia nigra (SNc) display distinctive anatomic and fun...

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Literature Corpus work: 1de95b6f-44a6-5250-a688-a3c695f90491
DOI: 10.1101/2024.06.06.597807

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