Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Preclinical studies and transcriptome analysis in a model of Parkinson’s disease with dopaminergic ZNF746 expression

28 Feb 2025

Abstract excerpt

BACKGROUND: The parkin-interacting substrate (PARIS, also known as ZNF746) is a transcriptional repressor, whose accumulation and phosphorylation play central pathological roles in Parkinson's disease (PD). PARIS-induced transcriptional repression of PGC-1α or MDM4 contributes to mitochondrial dysfunction and p53-dependent neuron loss in PD. Despite the important role of PARIS in PD pathogenesis, unbiased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40022229
DOI: 10.1186/s13024-025-00814-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preclinical studies and transcriptome analysis in a model of Parkinson’s disease with dopaminergic ZNF746 expressionPMID 40022229Read ↗

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal SurvivalSemantic proximity Read ↗

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's DiseaseSemantic proximity Read ↗

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson’s disease mouse brainSemantic proximity Read ↗

A Transcriptomic Roadmap of Parkinson’s Disease Progression at Single Cell ResolutionSemantic proximity Read ↗

Molecular and cellular signatures differentiate Parkinson’s disease from Parkinson’s disease with dementiaSemantic proximity Read ↗

Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson’s diseaseSemantic proximity Read ↗

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiencySemantic proximity Read ↗

Integrative Transcriptomic and Machine Learning Analysis Reveals a Robust Gene Signature in Parkinson’s DiseaseSemantic proximity Read ↗

An isogenic single-cell atlas of familial Parkinson’s disease mutations reveals convergent changes in dopamine neuronsSemantic proximity Read ↗

Parkinson’s Disease: Overview of Transcription Factor Regulation, Genetics, and Cellular and Animal ModelsSemantic proximity Read ↗

L-DOPA induces spatially discrete changes in gene expression in the forebrain of mice with a progressive loss of dopaminergic neuronsSemantic proximity Read ↗

Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.