Article

Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons

2025-06-15

Abstract excerpt

<h4>ABSTRACT</h4> The basal ganglia and midbrain dopaminergic systems are critical for motor control, reward processing, and reinforcement learning, with dysfunction in these systems implicated in numerous neurodegenerative and neuropsychiatric disorders. To enable precise genetic targeting of key neuronal populations, we generated and characterized five knock-in mouse lines: Drd1-Cre, Adora2a-Cre, Drd1-FlpO, Ad...

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Literature Corpus work: b39f9920-ee0a-5b62-99b5-6e01ddee69a3
DOI: 10.1101/2025.06.15.659794

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