Article

Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson’s disease

2020-03-24

Abstract excerpt

We performed transcriptome analysis using RNA sequencing on substantia nigra pars compacta (SNpc) from mice after acute and chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment and Parkinson’s disease (PD) patients. Acute and chronic exposure to MPTP resulted in decreased expression of genes involved in sodium channel regulation. However, upregulation of pro-inflammatory pathways was seen after si...

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Literature Corpus work: 85babd58-ad8a-5c7c-87db-12f80780453b
DOI: 10.1101/2020.03.21.001552

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