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Article

Dynamic DNA Methylation Regulates Levodopa-Induced Dyskinesia

15 Jun 2016

Abstract excerpt

UNLABELLED: Levodopa-induced dyskinesia (LID) is a persistent behavioral sensitization that develops after repeated levodopa (l-DOPA) exposure in Parkinson disease patients. LID is a consequence of sustained changes in the transcriptional behavior of striatal neurons following dopaminergic stimulation. In neurons, transcriptional regulation through dynamic DNA methylation has been shown pivotal to many long-term...

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PMID: 27307239
DOI: 10.1523/jneurosci.0683-16.2016

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