Article

Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesia

2023-11-05

Abstract excerpt

L-DOPA-induced dyskinesia (LID) is a debilitating motor side effect arising from chronic dopamine replacement therapy with L-DOPA for the treatment of Parkinson disease (PD). The emergence of LID is linked to heightened sensitivity of striatal dopaminergic signaling and driven by abnormal fluctuations in synaptic dopamine levels following each administration of L- DOPA. This maladaptive plasticity narrows the ther...

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Literature Corpus work: 08a6f74d-6f8e-50d9-ab59-6d6a661ba602
DOI: 10.1101/2023.11.03.565591

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Differential activation states of direct pathway striatal output neurons associated with the development of L-DOPA-induced dyskinesiaDOI 10.1101/2023.11.03.565591Read

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