Article

Effects of L-DOPA on gene expression in the frontal cortex of rats with unilateral lesion of midbrain dopaminergic neurons

2020-04-30

Abstract excerpt

The development of Parkinson’s disease (PD) causes dysfunction of the frontal cortex, which contributes to hallmark motor symptoms and is regarded as one of the primary causes of the affective and cognitive impairments observed in PD. Treatment with L-DOPA alleviates motor symptoms but has mixed efficacy in restoring normal cognitive functions, which is further complicated by the psychoactive effects of the drug....

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Literature Corpus work: 1524061c-8d41-5f47-974a-791c23e92dfc
DOI: 10.1101/2020.04.28.063347

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