Article

Deciphering Regional Transcriptomic Alterations in a 6-OHDA Rat Model of Parkinson's Disease through Integrated Single Cell and Spatial Analyses

2025-06-12

Abstract excerpt

<title>Abstract</title> <p>Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra, yet the detailed spatial and temporal cellular responses to this loss remain unclear. We aimed to generate a high-resolution map of midbrain changes by integrating single-cell and spatial transcriptomics in a 6-hydroxydopamine rat model. Unbiased clustering of single-nu...

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Literature Corpus work: 6563fe68-9bbd-5621-b938-d97f87708d9b
DOI: 10.21203/rs.3.rs-6849869/v1

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