Article

Repurposed COMT Inhibitors Tolcapone and Entacapone Selectively Suppress Aggregation and Seeding of P301 Mutant TAU in Human Neuronal Models

2026-04-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Purpose</h4> Pathogenic aggregation and propagation of seed-competent TAU assemblies drive tauopathies. MAPT P301 mutations accelerate aggregation and enhance seed competence, yet pharmacological strategies selectively targeting these pathogenic species remain limited. We investigated whether the clinically approved catechol-O-methyltransferase inhibitors tolcapone (TOL) and...

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Literature Corpus work: f5e8608d-e84d-5ee9-b3f1-94b27167f5f7
DOI: 10.64898/2026.04.20.719548

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