Article
Structural and functional insights into the selective inhibition of mutant tau aggregation by purpurin and oleocanthal in frontotemporal dementia.
Protein science : a publication of the Protein Society - 1 Sept 2025
Goud Alladi Charanraj, Kozlov Ihor, Skoupilová Patricie, Malina Lukáš, Roy Sudeep, Das Viswanath
Abstract excerpt
Tau aggregation driven by microtubule-associated protein tau (MAPT) mutations is central to frontotemporal dementia pathology, yet no disease-modifying therapies effectively target mutant tau. Here, we identify purpurin (PUR) and oleocanthal (OLC) as selective inhibitors of mutant tau aggregation using peptide models spanning the R2R3 interface. Biophysical and cellular assays demonstrated that both compounds...
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