Article

Sensitive detection and propagation of brain-derived tau assemblies in HEK293 based wild-type tau seeding assays

2024-07-18

Abstract excerpt

The assembly of tau into filaments defines the tauopathies, a group of neurodegenerative diseases including Alzheimer’s disease (AD), Pick’s disease (PiD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). The seeded aggregation of tau has been modelled in cell culture using pro-aggregant modifications such as truncation of the N- and C-termini and point-mutations within the tau microtubule...

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Literature Corpus work: 5b1fc138-3836-5af0-8ff4-00b1983eee92
DOI: 10.1101/2024.07.18.604077

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