Article

Precision Proteoform Design for 4R Tau Isoform Selective Templated Aggregation

2023-08-31

Abstract excerpt

Prion-like spread of disease-specific tau conformers is a hallmark of all tauopathies. A 19-residue probe peptide containing a P301L mutation and spanning the R2/R3 splice junction of tau, folds and stacks into seeding-competent fibrils and induces aggregation of 4R, but not 3R tau. These tau peptide fibrils propagate aggregated intracellular tau over multiple generations, have a high β- sheet content, a colocaliz...

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Literature Corpus work: 49efa1d4-ae37-541c-bf67-7d94370e79f3
DOI: 10.1101/2023.08.31.555649

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