Article

Structure-specific Mini-Prion Model for Alzheimer’s Disease Tau Fibrils

2025-06-27

Abstract excerpt

A critical discovery of the past decade is that tau protein fibrils adopt disease-specific hallmark structures in each tauopathy. The faithful generation of synthetic fibrils adopting hallmark structures that can serve as targets for developing diagnostic and/or therapeutic strategies remains a grand challenge. We report on a rational design of synthetic fibrils built of a short peptide that adopts a critical stru...

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Identifiers and source

Literature Corpus work: ad7f013f-022d-58de-8acf-099c2f51e698
DOI: 10.1101/2025.06.23.661111

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