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Article

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

19 Dec 2017

Abstract excerpt

The accumulation of aberrantly aggregated MAPT (microtubule-associated protein Tau) defines a spectrum of tauopathies, including Alzheimer's disease. Mutations in the MAPT gene cause frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), characterized by neuronal pathological Tau inclusions in the form of neurofibrillary tangles and Pick bodies and in some cases glial Tau pathology....

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PMID: 29259137
DOI: 10.1074/jbc.m117.815357

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