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Article

Codon Deviation Coefficient: a novel measure for estimating codon usage bias and its statistical significance.

BMC bioinformatics - 22 Mar 2012

Zhang Zhang, Li Jun, Cui Peng, Ding Feng, Li Ang, Townsend Jeffrey P, Yu Jun

Abstract excerpt

BACKGROUND: Genetic mutation, selective pressure for translational efficiency and accuracy, level of gene expression, and protein function through natural selection are all believed to lead to codon usage bias (CUB). Therefore, informative measurement of CUB is of fundamental importance to making inferences regarding gene function and genome evolution. However, extant measures of CUB have not fully accounted for...

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Identifiers

PMID: 22435713
DOI: 10.1186/1471-2105-13-43
PMCID: PMC3368730

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Source receipt: pubmed, retrieved 7 Sept 2026.

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