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Article

Human cellular homeostasis buffers <i>trans</i> -acting translational effects of heterologous gene expression with very different codon usage bias

2021-12-10

Abstract excerpt

The frequency of synonymous codons in protein coding genes is non-random and varies both between species and between genes within species. Whether this codon usage bias (CUBias) reflects underlying neutral mutational processes or is instead shaped by selection remains an open debate, especially regarding the role of selection for enhanced protein production. Variation in CUBias of a gene (be it natural synonymous...

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Literature Corpus work
42fafb35-39b5-59c0-9b21-07fbc0f5bfb5
DOI
10.1101/2021.12.09.471957
Open publication

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Human cellular homeostasis buffers <i>trans</i> -acting translational effects of heterologous gene expression with very different codon usage biasDOI 10.1101/2021.12.09.471957
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