Article

<i>MAPT</i> expression is mediated by long-range interactions with <i>cis</i> -regulatory elements

2023-03-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Tauopathies are a group of neurodegenerative diseases driven by abnormal aggregates of tau, a microtubule associated protein encoded by the MAPT gene. MAPT expression is absent in neural progenitor cells (NPCs) and increases during differentiation. This temporally dynamic expression pattern suggests that MAPT expression is controlled by transcription factors and cis-regul...

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Literature Corpus work: f5691af3-4c2f-55ba-80ac-35ef3030534f
DOI: 10.1101/2023.03.07.531520

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