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Promoter mutagenesis and a massively parallel reporter screen of the <i>MAPT</i> locus identifies cis-regulatory elements and genetic variation effects

2026-03-09

Abstract excerpt

Tau neurofibrillary tangles are a hallmark of several neurodegenerative diseases called tauopathies, including frontotemporal dementia and Alzheimer’s Disease. Ongoing clinical trials for tauopathies seek to reduce Tau in the brain through immunotherapy, antisense oligonucleotides, and siRNA. MAPT codes for Tau, therefore understanding how the MAPT gene is regulated and the effect of genetic variation at its reg...

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Identifiers and source

Literature Corpus work
71ee38f3-fcfd-5e4b-a655-b4506d4c3921
DOI
10.64898/2026.03.06.710116
Open publication

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Promoter mutagenesis and a massively parallel reporter screen of the <i>MAPT</i> locus identifies cis-regulatory elements and genetic variation effectsDOI 10.64898/2026.03.06.710116
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