Article

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex

2025-06-03

Abstract excerpt

Single-cell spatial transcriptomes have demonstrated molecular and cellular diversity in the brain 1, 2, 3, 4, 5, 6, 7, 8 , but gene regulatory mechanisms underlying transcriptomic profiles and disease pathogenesis remain largely unknown in primates. Here we performed single-nucleus Assay for Transposase-Accessible Chromatin followed by sequencing (snATAC-seq) for ∼1.6 million cells from 142 cortical regions of t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22e9ccd1-4736-5d82-a2a2-b6f64e9fa2eb
DOI: 10.1101/2025.06.03.657577

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortexDOI 10.1101/2025.06.03.657577Read

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex.Semantic proximity Read

Spatially resolved gene regulatory and disease vulnerability map of the adult Macaque cortexSemantic proximity Read

A comparative atlas of single-cell chromatin accessibility in the human brainSemantic proximity Read

A single-cell multi-omic atlas spanning the adult rhesus macaque brainSemantic proximity Read

Single Cell Multiomics Across Nine Mammals Reveals Cell Type Specific Regulatory Conservation in the BrainSemantic proximity Read

ScISOr-ATAC reveals convergent and divergent splicing and chromatin specificities between matched cell types across cortical regions, evolution, and in Alzheimer’s DiseaseSemantic proximity Read

Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific <i>cis</i> regulatory elementsSemantic proximity Read

Epigenomic Profiling and Single-Nucleus-RNA-Seq Reveal <i>Cis</i> -Regulatory Elements in Human Retina, Macula and RPE and Non-Coding Genetic VariationSemantic proximity Read

Comparative single cell epigenomic analysis of gene regulatory programs in the rodent and primate neocortexSemantic proximity Read

Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortexSemantic proximity Read

Spatial and single-nucleus transcriptomic profile of a chimpanzee frontal poleSemantic proximity Read

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human CortexSemantic proximity Read