Article

Selective epigenetic regulation of IFN-γ signature genes by JAK inhibitor in inflammatory diseases

2024-08-06

Abstract excerpt

This study addresses the molecular mechanisms behind JAK inhibitors (JAKi)' epigenetic regulation of IFN-γ-induced genes in macrophages, key players in controlling inflammation in chronic diseases such as rheumatoid arthritis (RA) and COVID-19. Utilizing transcriptomic and epigenomic approaches, we reveal that JAKi selectively regulate gene programs in IFN-γ-activated human macrophages. Our single-cell analysis id...

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Literature Corpus work: 0d1d51ed-1c0e-55b8-83f9-e1c432ddcf96
DOI: 10.1101/2024.08.05.606293

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