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Article

Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases.

Human genetics - 1 Jun 2020

Salem Sandra, Salem David, Gros Philippe

Abstract excerpt

The transcription factor IRF8 (ICSBP) is required for the development and maturation of myeloid cells (dendritic cells, monocytes, macrophages), and for expression of intrinsic anti-microbial function such as antigen capture, processing and presentation to lymphoid cells, and for activation of these cells in response to cytokines and pro-inflammatory stimuli (IFN-γ, IFN-β, LPS). IRF8 deficiency in humans causes a...

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Source

Identifiers

PMID: 32232558
DOI: 10.1007/s00439-020-02154-2

Genes

CD14
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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