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IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic Mechanisms

2024-11-08

Abstract excerpt

Interleukin-10 (IL-10) is pivotal in suppressing inflammation and innate immune activation, in large part by suppressing induction of genes by potent inflammatory factors such as TLR ligands. Despite decades of research, molecular mechanisms underlying this inhibition have not been resolved. This study utilized an integrated epigenomic analysis of gene transcription, chromatin accessibility, histone modifications...

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Literature Corpus work
9be73b5e-3460-5993-b812-88f85c54a9cb
DOI
10.1101/2024.11.07.622491
Open publication

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IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic MechanismsDOI 10.1101/2024.11.07.622491
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