Article

Single-cell analysis of signalling and transcriptional responses to type I interferons

2023-07-03

Abstract excerpt

<h4>Summary</h4> Type I interferons (IFNs) play crucial roles in antiviral defence, autoinflammation and cancer immunity. The human genome encodes 17 different type I IFNs that all signal through the same receptor. Non-redundant functions have been reported for some type I IFNs. However, whether different type I IFNs induce different responses remains largely unknown. We stimulated human peripheral blood mononucl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fb02dcda-3957-5bee-801f-4f71b9bbadb8
DOI: 10.1101/2023.07.03.547491

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell analysis of signalling and transcriptional responses to type I interferonsDOI 10.1101/2023.07.03.547491Read

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasSemantic proximity Read

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasSemantic proximity Read

Decipher: A computational pipeline to extract context-specific mechanistic insights from single-cell profilesSemantic proximity Read

[Review] The Landscape of Interferons in Health and DiseaseSemantic proximity Read

Profiling transcription factor sub-networks in type I interferon signaling and in response to SARS-CoV-2 infectionSemantic proximity Read

Dynamic rewiring of the human interactome by interferon signallingSemantic proximity Read

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cellsSemantic proximity Read

G1/S Boundary Activates Interferon and Inflammatory Response GenesSemantic proximity Read

Expression signatures with specificity for type I and II IFN response and relevance for autoimmune diseases and cancerSemantic proximity Read

Type I IFN family members: similarity, differences and interaction.Semantic proximity Read

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cellsSemantic proximity Read

Measuring host immune response status by simultaneous quantitative measurement of activity of signal transduction pathways that coordinate functional activity of immune cells from innate and adaptive immune systemSemantic proximity Read