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Regulating IRFs in IFN Driven Disease

29 Mar 2019

Abstract excerpt

The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal roles in many aspects of the immune response, including immune cell development and differentiation and regulating responses to pathogens. Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream of pathogen recognition receptors that detect viral RNA and DNA. A fourth...

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PMID: 30984161
DOI: 10.3389/fimmu.2019.00325

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