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Article

Early transcriptional effects of inflammatory cytokines reveal highly redundant cytokine networks

9 Jan 2025

Abstract excerpt

Inflammatory cytokines are fundamental mediators of the organismal response to injury, infection, or other harmful stimuli. To elucidate the early and mostly direct transcriptional signatures of inflammatory cytokines, we profiled all immunologic cell types by RNAseq after systemic exposure to IL1β, IL6, and TNFα. Our results revealed a significant overlap in the responses, with broad divergence between myeloid...

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PMID: 39873673
DOI: 10.1084/jem.20241207

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